Unlike mealtime blends, the formulas in this Transformation Enzymes collection are designed to be taken between meals on an empty stomach. Options range from a high activity protease delivering 375,000 HUT per capsule from fungal cultures to a buffered version made with calcium citrate, along with blends that add bromelain, papain and antioxidant nutrients. Serving patterns vary: some call for one capsule twice daily, others for two capsules on rising and two before bed. The contents of most capsules may be emptied into a small amount of tepid water. Regular users often keep a set schedule, so larger bottle sizes can suit a longer routine. One bromelain formula should stay sealed under refrigeration.